Wednesday, November 30

Welcome – Kris Gunsalus, Dave Hill, Marian Walhout

Session I: Keynote I

Marc Vidal (CCSB, DFCI): Interactome Networks

Session II: ORFeome and clone utilization
Chair: Troy Moore

Gary Temple (NIH/NHGRI): Mammalian gene collection: setting the goals and the status of current programs

Philippe Lamesch (CCSB, DFCI): Towards a complete C. elegans and human ORFeome

Jim Hartley (SAIC Frederick/NCI): POETry: Choices, costs, and opportunities

Session III: Gene Expression Networks I
Chair: Fabio Piano

Fabio Piano ( New York University): From genome sequence to developmental networks in C. elegans

Jason Lieb ( University of North Carolina): Chromatin context and DNA binding-site utilization

Martha Bulyk (HMS/HST): Rapid, high-throughput analysis of the DNA binding specificities of transcription factors with protein binding microarrays

Zhiping Weng ( Boston University): Bidirectional promoters in the Human Genome

 A. J. Marian Walhout (University of Massachusetts Medical School): C. elegans transcription regulatory networks

Session IV: Keynote II

Francis Collins (NIH/NHGRI): Resources for the genomic revolution

Poster Session

Thursday, December 1

Welcome – Ed Benz, President, DFCI

Session I: Interaction Mapping and Modeling I
Chair: Marian Walhout

Charlie Boone ( University of Toronto): Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast

Tim Gardner ( Boston University): Genome-scale identification of microbial regulatory pathways

Job Dekker (University of Massachusetts Medical School): Connecting genomic elements

Jean-Francois Rual & Kavitha Venkatesan (CCSB, DFCI): A proteome scale map of the human interactome network

Session II: RNAi and microRNAs I
Chair: Kris Gunsalus

William Hahn (HMS, DFCI): Identifying genes required for mitotic progression through high-content screening of an arrayed lentiviral RNAi library

Norbert Perrimon (HMS): Update on HTS RNAi screens in Drosophila cells

Nikolaus Rajewsky ( New York University): Identification and Characterization of microRNA targets

Kris Gunsalus ( New York University): N-Browse: an interactive browser for navigating gene networks

Workshops

ORFeome Resources: Strategies for building and distributing

Validating Interaction Networks: Technologies and Strategies

Session III: Interaction Mapping and Modeling II
Chair: Tom Chappell

Igor Stagljar ( University of Toronto): Interactive proteomics of membrane proteins: the first seven years and beyond

Zoltan Oltvai (U niversity of Pittsburgh School of Medicine): Functional organization of cellular networks

Erich Wanker (Max Planck Institute of Molecular Genetics): Systematic interaction mapping: linking human proteins to cellular pathways and disease processes

Michael Yaffe (MIT): Exploring the Functional Genomics of the ORFeome Using In Vitro Expression Cloning

Session IV: Cancer and Disease
Chair: Stuart Milstein

Elizabeth Winzeler (Scripps Research Institute): Investigating the malaria ORFeome

Stuart Orkin (DFCI): Developing an interactome for stem cells

Bill Kaelin (DFCI): Imaging degradable luciferase fusion proteins

Dorit Arlt (DKFZ): Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle

Session V: Keynote III

George Church (HMS): The Personal Genome Project (PGP)

Friday, December 2

Session I: Network modeling
Chair: Kavitha Venkatesan

Fritz Roth (HMS): Trial by trees: an integrative graphical model for probabilistic gene function assignment

Mark Gerstein ( Yale University): Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome

Albert-László Barabási ( University of Notre Dame): Network Biology

Amira Djebbari (DFCI, HSPH): Construction of genetic networks from the biological literature and microarray data

Rune Linding ( Mt. Sinai Hospital – SLRI): Modular protein interaction networks - developing a toolbox for synthetic biology

Session II: RNAi and microRNAs II
Chair: Andy Fraser

Gary Ruvkun (MGH): Using RNAi to study RNAi mechanisms

Sarah Jenna ( McGill University): Integrative analysis of small G proteins in C. elegans

Cammie Lesser (HMS): Searching for heuristics to interpret interaction data: a case study in characterizing a pathogenic Shigella protein

Sabbi Lall ( New York University): Towards in vivo validation of predicted microRNA targets in C. elegans

Session III: Gene Expression Networks II
Chair: Bart Deplancke

Ian Hope ( University of Leeds): C. elegans promoteromics

Christian Grove (University of Massachusetts Medical School): Dimerization and Expression of C. elegans bHLH Transcription Factors

Denis Dupuy (DFCI): C. elegans localizome: clustering nematode expression patterns

Workshop Summary

Wrap up

 

We would like to thank the following organizations for their support of this conference and to education at Dana-Farber Cancer Institute: Open Biosystems, Invitrogen, Operon Biotechnologies, Qiagen, Agencourt & Modul-Bio