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7th Annual ORFeome Meeting: ORFeomes and Systems October 24 - 26, 2007 The Conference Center at Harvard Medical Hosted by the Center for Cancer Systems Biology (CCSB), Dana-Farber Cancer Institute Click on a speaker's name to reach his or her website. |
Wednesday, October 24
11:00 Registration
1:00 Welcome - Organizers: Kris Gunsalus, David Hill, Fritz Roth, Marian Walhout
1:15 Session I: Networks
Chair: Marc Vidal
Nevan Krogan (University of California, San Francisco) – Unbiased biology: Functional insights from genetic and protein-protein interaction data
Tony Pawson (Mount Sinai Hospital) – The evolution of phosphorylation interaction networks
Stephen Michnick (University of Montreal) – Local dynamics and global structure of the S. cerevisiae protein interactome in living cells
Kris Gunsalus (New York University) – Probing molecular networks in worm development
3:15 Coffee break
4:00 Session II: Diseasomics I
Chair: Michael Cusick
Huda Zoghbi (Baylor College of Medicine) – Pathogenic mechanism of a
polyglutamine neurodegenerative disorder: insight from the ataxia interactome
Michael Green (University of Massachusetts Medical School) – Studying the basis of oncogene-directed epigenetic silencing using a genome-wide shRNA screen
Yves Jacob (Institut Pasteur) – Mapping and comparative analysis of interaction networks between viral E6 and E7 proteins from 12 HPVs and human proteins
Albert-László Barabási (Northeastern University) – From the diseasome to human comorbidity patterns
6:00 Reception
Thursday, October 25
(Online version more recent that what is printed in the programs)
8:00 Breakfast
9:00 Session I: Diseasomics II
Chair:
Karl Munger
Vamsi Mootha (Massachusetts General Hospital) – Systems analysis of the mitochondrion through a tissue atlas of the organelle
Kornelia Polyak (Dana-Farber Cancer Institute) – Stem cells and cancer in the human breast
Yingchun Liu/Guo-Cheng Yuan (Dana-Farber Cancer Institute) – Revealing signaling pathway deregulation in specific subclasses of cancer
10:20 Coffee Break
10:45 Session II : ORFeomics
Chair: Gary Temple
George Weinstock (Baylor College of Medicine) – Bacterial clone sets
Osamu Ohara (Kazusa DNA Research Institute) – Kazusa ORFeome Project
Kourosh Salehi-Ashtiani (Dana-Farber Cancer Institute) – Towards completing human and C. elegans ORFeomes
12:15 Lunch
1:00 Poster Session
3:00 Session III: RNAomics
Chair: Kris Gunsalus
Dave Bartel (MIT) – MicroRNAs
Phil Zamore (University of Massachusetts Medical School) – Small RNA diversity and function
Troy Moore (Open Biosystems) – GIPZ: lentivirial shRNAmir-GFP libraries for mammalian RNAi
4:30 Coffee Break
5:00 Session IV: Genetic Networks
Chair: Fritz Roth
Mark Siegal (New York University) – A systems-level view of evolutionary robustness
Charlie Boone (University of Toronto) – Global mapping of genetic and chemical-genetic networks in yeast
Rune Linding (SLRI - MIT) – Casting a net for kinases: Systematic discovery of in vivo phosphorylation networks
6:15 Reception
7:00 Dinner
Friday, October 26
8:00 Breakfast
9:00 Session I: Network Dynamics I
Chair: Pascal Braun
Oliver Rando (University of Massachusetts Medical School) – Static and dynamic genome-wide views of yeast chromatin
Tae Hoon Kim (Yale University) – Genome-wide function of CTCF
Marian Walhout (University of Massachusetts Medical School) – Integrated C. elegans transcriptional and post-transcriptional regulatory networks
10:30 Coffee Break
11:00 Session II: Network Dynamics II
Chair: Marian Walhout
Aviv Regev (MIT) – Natural history and evolutionary principles of gene duplication in fungi
Martha Bulyk (Harvard Medical School) – Systematic identification of mammalian regulatory motifs' target genes and functions
Marcus Noyes (University of Massachusetts Medical School) – A recognition code for homeodomains derived from a comprehensive analysis of factors in D. melanogaster
12:30 Lunch
2:00 Session III: Systems I
Chair:
Brett Tyler (Virginia Tech) – Inferring genetic regulatory networks in host-pathogen interactions
Hunter Fraser (Broad Institute) – Common polymorphic transcript variation in humans
Oaz Nir (MIT) – Inference of gene networks using quantitative morphological signatures
3:15 Coffee Break
3:45 Session IV: Systems II
Chair: Jim Hartley
Yo Suzuki (Harvard Medical School) – Green monster, a method for routinely engineering S. cerevisiae strains with multiple precise deletions
Jean-Thierry Mieg (NLM, NIH) – The wonderful complexity of the human genes
Marc Vidal (Dana-Farber Cancer Institute) – High-quality high-throughput interactome network maps
5:00 Wrap-up
